【摘要】 眼内新生血管是很多眼病致盲的重要原因,例如糖尿病视网膜病变、年龄相关性黄斑变性、早产儿视网膜病变、视网膜中央或分支静脉阻塞、角膜炎和眼外伤等。生长因子中的血管内皮生长因子(vascular endothelial growth factor,VEGF)家族是眼内血管新生的关键因素。在一些眼病中,它通过调控病理性血管发生和增加血管通透性而起作用。本文我们主要阐述眼内新生血管的形成机制和治疗方面的新进展,对VEGF家族的结构、理化特性、VEGF及受体在眼内血管新生中的作用以及针对血管新生的防治措施进行综述。更多还原

【Abstract】 Ocular neovascularization is the primary cause of blindness in a wide range of ocular diseases,such as diabetic retinopathy,age-related macular degeneration,retinopathy of prematurity,central and branch retinal vein occlusion,infectious keratitis and trauma.The growth factors in the vascular endothelial growth factor(VEGF) family are the key factors involved in ocular neovascularization,which can cause critical eye diseases through pathologically regulated angiogenesis and increased vascular permeability.In this article,we illustrate the mechanisms of ocular neovascularization and introduce the most recent progresses in the treatment of neovascularization.Meanwhile,we also review the structural and physicochemical characteristics of VGEF family,the effect of VEGF and its receptor on ocular neovascularization and the measures to inhibit neovascularization.更多还原