【摘要】 目的分析原发性醛固酮增多症(PA)的临床表现、辅助检查及治疗情况。方法对1999年7月至2005年3月间连续确诊的105例患者的临床资料进行回顾性分析。结果89例患者中有低血钾者占85%,血浆立、卧位肾素活性处于正常低值,立、卧位醛固酮水平均增高。醛固酮和肾素活性比值(ARR)>25者占71%,ARR>50者占8%。81例行B超检查,99例行CT检查,20例行MRI检查,其阳性率分别为:51.9%,80.8%,85%。58例原发性醛固酮增多症患者行手术治疗,其中43例血压均恢复正常,15例仍需要药物继续控制血压。结论血浆肾素活性,血浆醛固酮水平,以及血浆醛固酮和肾素活性比值(ARR)是原发性醛固酮增多症的主要定性诊断方法。CT是原发性醛固酮增多症的主要定位诊断依据。外科手术是治疗原发性醛固酮增多症的重要方法。更多还原

【Abstract】 Objective To explore the clinical symptoms,examination methods and treatment of primary aldosteronism(PA). Methods The clinical data of 105 PA patients admitted from July,1999 to March 2005 were retrospectively reviewed. Results Eighty-nine patients had hypokalemia(85%).All the patients underwent periplasmal renin activity(PRA),aldosterone(ALD) test.PRA level was decreased and ALD level was increased.71% patients had ALD/PRA ratio(ARR)>25 and 8% patients had ARR>50.Eight-one patients received B ultrasonography,99 patients received computer tomography(CT) and 20 patients received magnetic resonance imaging(MRI) examination.The positive rates for detecting adrenal hyperplasia or adenoma of B ultrasonography,CT or MRI were 51.9%,80.8% and 85% respectively.Fifty-eight PA patients underwent surgery,the blood pressure was normalized in 43 patients,15 patients still need anti-hypertensive treatment. Conclusions PRA,ALD and ARR test are the main methods for PA qualitative diagnosis;CT is useful for the PA niveau diagnosis.Surgical method is the main treatment for PA.更多还原