【摘要】 目的评价经皮冠状动脉介入治疗(PCI)急性心肌梗死恢复期对患者左室重构的临床作用。方法对50例首次心肌梗死患者,平均于发病(3.8±2.1)周行冠状动脉造影,并进行前瞻性研究。按梗死相关冠状动脉是否进行PCI及PCI成功与否分为PCI组(28例PCI成功患者)和对照组(22例未行PCI患者)。对PCI组患者,于术前[平均(4.5±3.3)d]及术后随访期[平均(6.9±1.3)个月]及对照组患者于相当于PCI组术前和随访期时间进行心脏超声检查,以评价左室容量和收缩及舒张功能的改变。结果PCI组术后随访期左室容量较术前减小、左室收缩功能明显改善,而左室舒张功能无明显变化。与对照组相比,PCI组随访期左室容量较小,而收缩及舒张功能明显好于对照组。结论在心肌梗死恢复期,PCI尚能阻止患者的左室重构,改善患者的远期左室功能,具明显临床有益作用。更多还原

【Abstract】 Objective To assess the impact of percutaneous coronary intervention(PCI) performed during recovery phase on left ventricular(LV) remodeling in acute myocardial infarction(AMI) patients.Methods Twenty-eight patients(group Ⅰ) with first-time MI and having received successful PCI during recovery phase were prospectively studied;22 patients(group Ⅱ) with first-time AMI but without receiving PCI were enrolled as control.In both groups,serial echocardiographic examinations were performed before PCI [(4.5±3.3) days] and during follow up [(6.9±1.3) months after PCI] to assess the changes in LV volumes,systolic and diastolic function. Results In group Ⅰ,LV volume was decreased and systolic function was improved after PCI during follow-up,but LV diastolic function remained unchanged.LV volume was smaller and systolic and diastolic function was better in group Ⅰ than in group Ⅱ(all P<0.05). Conclusions PCI performed during the recovery phase of acute myocardial infarction may significantly improve the heart function.更多还原