【摘要】 目的为了解细菌耐药性变化趋势,对某医院近5年住院病人多重耐药菌感染率及耐药菌的变迁进行回顾性调查分析。方法进行细菌培养,共分离3 564株多重耐药菌,药敏结果判断依据NCCLS2002年标准,并排除同一患者的重复菌株。结果住院病人多重耐药菌感染率为1.87%,耐甲氧西啉金黄色葡萄球菌平均感染率为0.38%,耐甲氧西啉凝固酶阴性葡萄球菌平均感染率为1.17%,产超广谱β-内酰胺酶的肺炎克雷伯氏菌平均感染率为0.09%,肺炎克雷伯氏菌之外的产超广谱β-内酰胺酶的肠杆菌平均感染率为0.23%,未发现耐万古霉素的肠球菌。2003-2007年的MRSA、MRCNS的构成比有显著的变化,ESBLKp和ESBLE构成比变化不明显。结论结果显示五年内MRSA、MRCNS的感染率逐年升高;ESBLKp、ESBLE感染率变化小,但均无明显差异。更多还原

【Abstract】 Objective The objective of this study was to determine the incidence of multidrug-resistant bacteria in hospitalized patients.Methods This study was conducted in a hospital in XiangFan,Hubei Province from 2003 to 2007.We recorded all isolations of multidrug-resistant bacteria from clinical samples that were obtained from hospitalized patients and drug sensitivity test is based on the standard of NCCLS2002.The same strains that were isolated form a patient were excluded.Result The gross incidences of patients were 1.87% for multidrug-resistant bacteria.The mean infection rate were 0.38% for methicillin-resistant Staphylococcus aureus,1.17% for methicillin-resistant coagulase-negative Staphylococci,0.09% for extended-spectrum ?-lactamase-producing Klebsiella pneumoniae,0.19 for extended-spectrum ?-lactamase-producing Enterobacteriaceae other than Klebsiella pneumoniae,and no for vancomycin-resistant Enterococcus.From 2003 to 2007,the composition ratio of MRSA and MRCNS were notable changes.ESBLKp and ESBLE changes little.Conclusion The results showed that the infection rate of MRSA and MRCNS increased,ESBLKp and ESBLE changes little within five years,but no significant difference.更多还原