【摘要】 [目的]探讨人乳头状瘤病毒(HPV)在新疆哈萨克族食管癌、癌旁组织及正常食管黏膜组织中的感染情况及感染后意义。[方法]采用聚合酶链反应(PCR)技术检测80例食管鳞癌和对应80例癌旁正常鳞状上皮组织及80例正常食管黏膜组织中HPV感染情况,采用χ2检验分析HPV感染与食管癌发生发展的相关性。[结果]80例食管癌组织、癌旁组织及正常食管黏膜组织中HPV感染阳性率分别为42.5%、25%、13.75%。统计学结果显示食管癌组与癌旁正常鳞状上皮组及正常食管黏膜组HPV感染,差异有统计学意义(χ2=17.006,P﹤0.05)。[结论]新疆哈萨克族食管癌组织中存在HPV感染,HPV感染可能与食管癌的发生、发展有关。更多还原

【Abstract】 [Objective]To detect the HPV infection in Xinjiang Kazakh esophageal carcinoma,normal tissues beside the tumor and normal esophagus mucosal and to investigate the association between HPV infection and etiology and carcinogenesis of Kazakh esophageal carcinoma in Xinjiang.[Methods]Detected the HPV infection in 80 Kazakh esophageal carcinoma,80 normal tissues beside the tumor and 80 normal esophagus mucosa by polymerase chain reaction(PCR)and validated them by sequencing PCR product selected in the 240 samples randomly and χ2 test was used.[Results]The positive rate of HPV16 in Kazakh esophageal carcinoma,normal tissues beside the tumor and normal esophagus mucosa was 42.5%,25%,13.75% respectively,which had statistical significance among them(P = 0.000﹤ 0.05).[Conclusion]It indicates that HPVDNA may exist in Kazakh ESCC. There is a correlation between HPVDNA infection and the development of Kazakh ESCC in Xinjiang.更多还原