【摘要】 [目的]了解乙型肝炎免疫球蛋白(HBIG)阻断乙型肝炎病毒母婴传播的效果,为制定防治对策提供科学依据。[方法]研究对象分为4组,第1组HBsAg阳性孕妇使用HBIG,其新生儿联合使用HBIG和乙肝疫苗;第2组HBsAg阳性孕妇不使用HBIG而其新生儿使用HBIG;第3组HBsAg阳性孕妇不使用HBIG,其新生儿单独使用乙肝疫苗;第4组HBsAg阴性母亲的新生儿单独使用乙肝疫苗。乙肝疫苗全程免疫12月后测定HBsAg和抗-HBs。[结果]HBsAg阳性孕妇及其新生儿使用HBIG组HBsAg阳性率1.17%低于HBsAg阳性孕妇未使用HBIG而其新生儿使用HBIG组6.10%,差异有统计学意义,抗-HBs阳性率68.48%高于HBsAg阳性孕妇未使用HBIG而其新生儿使用HBIG组40.24%,差异有统计学意义。[结论]HBsAg阳性孕妇及新生儿使用HBIG组免疫效果优于未使用组。更多还原

【Abstract】 ObjectiveTo explore the effect of hepatitis B immune globulin(HBIG)on interrupting vertical transmission of HBV from mothers to babies,so as to provide scientific basis for formulating countermeasures for prevention and control.MethodsThese participants were divided into four groups. HBIG were injected to the pregnant with positive HBsAg,and HBIG and HBV vaccines were injected to the newborns in first group;For the second group,the newborns were treated with HBIG which were not used for their mothers;For the third group,the pregnant did not treated with HBIG,while their newborns were treated with HBV vaccine;For the forth group,the pregnant and their newborns were separately injected with HBV vaccine. The HBsAg and anti-HBs were detected after vaccinating three 10μg doses of HBV vaccine.ResultsIn the first group,the positive rate of HBsAg was 1.17% for newborns which were significantly lower than that in the second group with the rate of 6.10%. The positive rate of anti-HBs was 68.48% in the first group was significantly higher that that in the second group with the rate of 40.24%.ConclusionTHE immune effect of pregnant and newborns were both treated with HBIG was significantly better than that without treating with HBIG.更多还原