【摘要】 [目的]研究叶枯唑原药对大鼠的主要亚慢性毒性作用,确定最大无作用剂量及毒作用靶器官。[方法]按照GB15670-1995《农药登记毒理学试验方法》中大鼠亚慢性经口毒性试验方法进行,设0,7.0,27.9,111.7,447.0mg/kg 5个剂量组。[结果]与对照组相比,高剂量组(447.0 mg/kg)体重增长明显减慢(P﹤0.01);脏器系数检查显示低、中、高剂量组甲状腺脏体比均较对照组高(P﹤0.01);组织病理学检查见低、中、高剂量组大鼠甲状腺不同程度的增生,且呈现良好的剂量-反应关系。[结论]大鼠经口染毒叶枯唑原药90 d的最大无作用剂量雌雄鼠均为7.0mg/kg,甲状腺为叶枯唑毒作用的靶器官。更多还原

【Abstract】 [Objective]To study the subchronic toxicity of bismerthiazol on rats and to obtain its NOAEL and targeted organs.[Methods]According to the subchronic oral toxicity testing method listed in the Toxicological Testing Methods for Pesticide Registration(GB15670-1995),5 doses groups(0,7.0,27.9,111.7,447.0 mg/kg)were set up.[Results]The body weights of rats in high dose group(447.0 mg/kg)were significantly less than those of the groups(P﹤0.01);the ratios of thyroid gland weights in 27.9,111.7,447.0 mg/kg group were higher than that in the control group,and pathological examination showed that thyroid glands had different hyperplasia degrees in all groups and a good dose-response relationship.[Conclusion]The 90 days NOAEL of bismerthiazol is 7.0 mg/kg in both female and male rats,and targeted organ of toxic effects is thyroid gland.更多还原