【摘要】 目的观察氨磷汀对顺铂所致肾毒性的预防性保护作用。方法随机将大鼠分成5组,即空白对照组,顺铂5mg·kg-1组,顺铂7.5mg·kg-1组,顺铂5mg·kg-1+氨磷汀200mg·kg-1组和顺铂7.5mg·kg-1+氨磷汀200mg·kg-1组,分别测定肾脏脏器系数、血尿素氮、肌酐水平,并做肾组织病理学检查。结果顺铂5mg·kg-1及7.5mg·kg-1组大鼠BUN、Cr值均明显高于对照组和加用氨磷汀组,差异有显著性(P<0.05或P<0.01);氨磷汀组肾脏脏器系数明显下降,病理分级显示氨磷汀肾损害保护率分别为61.5%和56.8%。结论氨磷汀能有效地预防顺铂所致肾毒性。更多还原

【Abstract】 OBJECTIVE Amifostine,a cytoprotector of broad-spectrum,protects normal tissues from the toxic effects of certain anticancer drugs.This study aims to observe the protective effect of amifostine angainst cisplatin-induced nephrotoxicity.METHODS Thirty-five Sprague-Dawley rats were randomly divided into 5 groups:control group(0.9% saline solution),cisplatin 5 mg·kg-1 group,cisplatin 7.5 mg·kg-1 group,cisplatin 5 mg·kg-1+amifostine 200 mg·kg-1 group and cisplatin 7.5 mg·kg-1+amifostine 200 mg·kg-1 group.Organ coefficient of kidneies,serum BUN,creatinine were measured.Renal histopathological lesions were examined by light microscopy.RESULTS Compared with control group and cisplatin 5 mg·kg-1+amifostine 200 mg·kg-1 or cisplatin 7.5 mg·kg-1+amifostine 200 mg·kg-1 group,serum BUN and creatinine were significantly elevated in cisplatin 5 mg·kg-1 and cisplatin 7.5 mg·kg-1 groups(P<0.05 or P<0.01).The organ coefficients of kidneies with amifostine were decreased obviously.The rate of nephroprotection in pathological grade was 61.5% and 56.8%,respectively.CONCLUSION Amifostine is able to protect the nephrotoxicity induced by cisplatin.更多还原