【摘要】 目的探讨HLA-DRB1基因多态性与湘西土家族人群不明原因反复流产的遗传关联性。方法采用聚合酶链反应-序列特异性引物(PCR-SSP)技术,对76例湘西土家族不明原因反复流产患者和82例湘西土家族健康对照者的HLA-DRB1等位基因进行分析。结果与对照组比较,病例组的DRB1*04基因频率增高(37.17%比8.27%,PC<0.01,RR=8.02),而DRB1*12基因频率显著低于对照组(4.72%比28.43%,PC<0.01,RR=0.11)。结论HLA-DRB1*04可能是湘西土家族不明原因反复流产的易感基因,HLA-DRB1*12可能为保护基因。更多还原

【Abstract】 Objective It is to discuss the genetic relevance between HLA-DRBl gene polymorphism and unexplained recurrent spontaneous abortions(URSA) in Xiangxi Tujia nationality crowd.Methods HLA-DRB1 alleles in 76 Xiangxi Tujia nationality URSA patients and 82 Xiangxi Tujia nationality healthy collators were analyzed with PCR-SSP technique.Results Compared with control group,the frequency of DRBl*04 allele in patient group was heightened(37.17% vs 8.27%,PC<0.01,RR=8.02),but the frequency of DRBl*12 allele was lowered(4.72% vs 28.43%,PC<0.01,RR=0.11).Conclusion DRBl*04 maybe is the predisposing genes of Xiangxi Tujia nationality URSA and DRBl*12 maybe is the protection genes.更多还原