【摘要】 目的探讨静脉用丙种球蛋白(IVIG)治疗新生儿ABO溶血病临床效果。方法将48例新生儿ABO溶血病的患儿随机分为IVIG组和对照组,对照组给予常规治疗。IVIG组在对照组基础上给予IVIG,观察血清总胆红素及间接胆红素的动态变化,黄疸消退时间、住院时间、血红蛋白、网织红细胞的变化。结果IVIG组血清总胆红素及间接胆红素在治疗后24h、48 h7、2 h较对照组明显降低(P<0.001);IVIG组血红蛋白、网织红细胞治疗前后无明显改变(P>0.05);IVIG组治疗后黄疸消退快(P<0.01),住院时间短(P<0.01)。结论IVIG具有免疫封闭作用,能阻止新生儿溶血病的溶血过程,可降低血清胆红素水平,缩短病程。更多还原

【Abstract】 Objective It is to discuss the clinical effect of Gammavenin(IVIG) on newborn ABO haemolytic disease.Methods 48 newborns with ABO haemolytic disease were randomly divided into IVIG group and control group.Control group was treated with conventional treatment.On the basis of the control group,IVIG group was added IVIG.The dynamic changes of serum total bilirubin and indirect bilirubin and others changes such as the time of jaundice disappearance,the length of stay,the value of hemoglobin and reticulocyte were observed.Results The serum total bilirubin and indirect bilirubin in IVIG group at 24 h,48 h,72 h after treatment were obviously lower than that in control group(P<0.001).The hemoglobin and reticulocyte in IVIG group after treatment had no obvious change compared with that before treatment(P>0.05).Jaundice in IVIG group after treatment decreased fast(P<0.01).The length of stay in IVIG group was short(P<0.01).Conclusion IVIG has immunical blockage which can block haemolytic procedure of newborn haemolytic disease,lower serum bilirubin level and shorten the course of treatment.更多还原