【摘要】 目的分析60例亚临床甲状腺功能减退症(亚临床甲减)患者血脂、血糖、血尿酸水平变化及其临床意义。方法测定60例亚临床甲减患者的血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、血糖(GLU)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血尿酸(UA)水平,并据TSH浓度分为Ⅰ亚组(TSH<10.0 mIU/L)和Ⅱ亚组(TSH≥10.0 mIU/L),分别与56例健康对照组比较及行亚组间比较。结果与健康对照组比较,亚临床甲减组及2个亚组的TSH、TC、TG、LDL-C、UA水平明显升高,而HDL-C明显下降,有显著性差异(P均<0.05),尤以Ⅱ亚组的TC、TG、LDL-C、UA升高最明显(P均<0.01);2个亚组间的TC、TG、LDL-C、UA、HDL-C水平也有显著性差异(P均<0.05);而血糖水平虽有轻微下降,但均无显著性差异。结论亚临床甲减组及2个亚组的TC、TG、LDL-C、HDL-C、UA水平有明显差异,而血糖变化则无显著性差异。亚临床甲减在促进动脉粥样硬化的过程中,血脂代谢紊乱和高尿酸血症可能是重要的危险因素,而与血糖变化无关。更多还原

【Abstract】 Objective It is to analyze the variety and the clinic signification of lipids,plasma glucose,blood uric acid in patients with subclinical hypothyroidism.Methods The levels of TSH,FT3,FT4,FPG,TC,TG,LDL-C,HDL-C and UA were measured in 60 patients with subclinical hypothyroidism.The patients were divided into two groups according to TSH level: sub-groupⅠ(TSH<10.0 mIU/L) and sub-groupⅡ(TSH≥10.0 mIU/L),then,compared with 56 control subjects,and compared with each other.Results Compared with control subjects,patients with subclinical hypothyroidism,as well as patients with that two groups had higher TSH,TC,TG,LDL-C,UA;and lower HDL-C(P<0.05).Especially,the sub-group Ⅱ had higher TC,TG,LDL-C and UA(all P<0.01).Both sub-groupⅠ and sub-groupⅡ showed a significant difference in TC,TG,LDL-C,UA,HDL-C(P<0.05),FPG were no different.Conclusion Both group of subclinical hypothyroidism and two sub-groups show a significant difference in TC,TG,LDL-C and UA,except FPG.Within subclinical hypothyroidism patients,lipid dysfunction and high uric acid may be important risk factors for the development of atherosclerotic cardiovascular disease,there is no correlation with PFG.更多还原