【摘要】 目的探讨复发性生殖器疱疹(RGH)患者抑郁情绪障碍与细胞免疫功能的关系。方法采用自评抑郁量表(SDS)对66例RGH患者进行情绪评定,并比较分析抑郁者与无抑郁者的外周血单一核细胞(PBMC)产生白细胞介素2(IL-2)的能力、天然杀伤(NK)细胞活性。结果RGH患者的SDS评分明显高于对照组(P<0.01).抑郁障碍的发生率为51.51%。RGH患者中,治疗时间>3个月者比治疗时间<3个月者抑郁均分显著增高(P<0.05);未生育者比已生育者抑郁均分显著增高。具有抑郁情绪障碍者,PBMC产生IL-2的能力、NK细胞活性明显降低(P<0.01)。结论RGH患者存在明显的抑郁情绪障碍问题,且抑郁者细胞免疫功能低下。更多还原

【Abstract】 Objective To evaluate the possible association of depression with cellular immunologic status in patients with recurrent genital herpes(RGH).Methods Depression was assessed with the self-rating depression scale(SDS),and the activity of natural killer(NK)cells and inteleukin-2(IL-2)produced by peripheral blood mononuclear cells(PBMC) were measured in 66 patients with RGH.Results The SDS scores in patients with RGH were significantly higher than those in the controls(P<0.01),and 51.51% of the patients were affected by depression.The mean scores of depression among patients with long duration of treatment(>3months)were significantly higher than those in patients with short du- ration(<3months) (P<0.05).The mean scores of depresion among patients without child birth were significantly higher than those in patients with child birth(P<0.01).In patients affected by depression,the level of IL-2 produced by PBMC and the activity of NK cells were significantly decreased(P<0.01).Conclusions Patients with RGH are usually affected by depression and the cellular immunologic status is usually impaired among the patients with depression.更多还原