【摘要】 目的观察中药艾灵颗粒治疗艾滋病病毒(HIV)感染者外周血树突状细胞(Dendritic cell,DC)亚群变化特点。方法收集未接受高效抗逆转录病毒治疗(HAART)的17例HIV感染者,采用中药艾灵颗粒治疗9个月,11例健康人作为对照,观察治疗前后症状体征变化。采用流式细胞技术对患者外周血髓样树突状细胞(MDC)及浆细胞样树突状细胞(PDC)频率进行检测,并对PDC产生α-干扰素(IFN-α)能力进行检测。结果疗后3个月、9个月,MDC频率与疗前的差异有统计学意义(P<0.05),疗后9个月,PDC频率与疗前的差异有统计学意义(P<0.05),均从疗前低于健康对照水平恢复到疗后健康对照水平。疗后9个月IFN-α均值升高,与疗前的差异有统计学意义(P<0.01)。结论艾灵颗粒可能在一定程度恢复MDC和PDC频率,升高PDC分泌IFN-α的作用,提高感染者免疫功能。更多还原

【Abstract】 Objective To investigate the change of peripheral dendritic cell(PDC)subsets in individuals infected with HIV who were treated with Ailing granule,a traditional Chinese drug.Method Seventeen cases who had not taken anti-viral medicines were treated with AiLing granule for 9 months.Eleven cases were set as normal control.The percentages of PDC and MDC were determined by flow cytometry.At the same time,the ability of PDC to produce IFN-α was also detected.Results The percentage of MDC in individuals treated with Ailing granule for 3 or 9 months was significantly higher than that before the treatment,and returned to a normal level.The percentage of PDC in individuals treated for 9 months was significantly higher than that before-treatment and also returned to a normal level.The value of IFN-α in individuals treated for 9 months was elevated and had statistically significant difference as compared with that before treatment.Conclusion Ailing granule could increase to a certain extent the percentages of MDC and PDC and elevate the ability of PDC to produce IFN-α,thus raising immunity of the infected individuals.更多还原