【摘要】 目的揭示糖尿病对大鼠外周血中性激素水平的影响。方法用放射免疫法分别检测糖尿病(DM)大鼠10只,正常(NDM)大鼠10只和STZ大鼠10只外周血清中睾酮、促黄体生成素(LH)和促卵泡刺激素(FSH)的含量。结果DM组睾酮水平显著低于NDM组、STZ组(P<0.01),NDM组与STZ组之间则无显著性差异(P>0.05);DM组促黄体生成素(LH)水平显著高于NDM组、STZ组(P<0.01);NDM组与STZ组之间,LH水平无显著性差异(P>0.05);促卵泡刺激素(FSH)水平在各组之间无显著性差异(P>0.05)。结论糖尿病大鼠血清睾酮水平显著降低,机制可能与糖尿病致睾酮合成与分泌降低有关。更多还原

【Abstract】 Objective To explore the effect of diabetes mellitus on the contents of serum sex hormones in male rats.Methods Detected the contents of serum testosterone,luteinizing hormone(LH) and follicle-stimulating hormone(FSH) in diabetic(DM) rats,normal(NDM) rats and STZ rats with radioimmunoassay.Results The testosterone in DM group was lower than that of the NDM group and STZ group(P<0.01);The testosterone in NDM group and STZ group is inconsequential(P>0.05);The LH in DM group was higher than that of the NDM group and STZ group(P<0.01);The LH in NDM group and STZ group is inconsequential(P>0.05);The FSH is inconsequential(P>0.05).Conclusion The decreasing of the contents of testosterone was affected by DM and the decreasing of the synthesis of testosterone may be one of the most important mechanisms.更多还原