【摘要】 目的探讨河南贲门癌高发区贲门癌组织中sPLA2(Ⅱa)的表达。方法采用免疫组化卵白素-生物素-过氧化物酶复合物(ABC)法分析80例贲门癌组织和16例贲门癌旁肠化组织中sPLA2(Ⅱa)的表达情况。结果sPLA2(Ⅱa)在癌旁肠化组织中的表达高于贲门腺癌组织(75.0%vs37.5%,P<0.05),高、中、低分化贲门腺癌sPLA2(Ⅱa)阳性率分别为38.5%、27.6%、48.0%,三组表达率差异无统计学意义(P>0.05)。结论sPLA2(Ⅱa)可能参与了贲门癌的癌变过程。更多还原

【Abstract】 Objective To characterize the alterations of sPLA2(Ⅱa) in gastric cardiac adenocarcinoma(GCA) from the high-incidence area for GCA in Henan.Methods sPLA2(Ⅱa) expression was detected by immunohistochemical method(ABC) in 80 GCA patients and 16 cases with intestinal metaplasia(IM) adjacent to gastric cardia adenocarcinoma(GCA).Results The positive rate of sPLA2(Ⅱa) in intestinal metaplasia was higher than that in GCA(75.0% vs 37.5%,P<0.05).The positive sPLA2(Ⅱa) expression in advanced,moderately differentiated and poorly differentiated GCA were 38.5%,27.6%,48.0%,respectively,and the difference was not significant(P>0.05).Conclusion sPLA2(Ⅱa) may play an important role in the carcinogenesis of GCA.更多还原