【摘要】 目的探讨汉族人群溃疡性结肠炎(UC)易感性与谷胱甘肽转硫酶(GST)P1基因型的关系。方法用聚合酶链反应技术(PCR)检测76例溃疡性结肠炎(UC)和140例健康人群的GSTP1基因型,采用χ2检验,分析比较GSTP1基因型频率在UC组和健康对照组之间的分布差异。结果GSTP1基因VaL/VaL基因型频率在UC组中明显增高,有统计学差异(48.7%vs34.3%,P=0.039);根据临床特征对UC组和进行分层分析,发现VaL/VaL基因型在远端UC中的分布频率高于广泛结肠UC(P=0.017)。结论GSTP1基因型与中国汉族人群UC的易感性相关。更多还原

【Abstract】 Objective To investigate the association between the genotype of glutathione S-transferase P1 and the susceptibility to ulcerative colitis(UC) in Chinese Hans.Methods Polymerase chain reaction(PCR) was used in the study of GSTP1 genotype, then analysed the discrepancies of GSTP1 genotype frequences between 76 UC patients and 140 healthy controls by χ2 test.Results The frequency of VaL/VaL genotype was higher in the UC patients than that in the controls (48.7% vs 34.3%,P=0.039). According to the clinical features of UC patients, the frequency of VaL/VaL genotype was also higher in distal colon patients than that in total colon patients(P=0.017).Conclusion The GSTP1 genotype is strongly correlated with the susceptibility to ulcerative colitis in Chinese Hans.更多还原