【摘要】 基质金属蛋白酶是降解肌腱细胞外基质蛋白的重要蛋白酶,在肌腱重塑中具有重要的作用。一些基质金属蛋白酶对保持肌腱的健康是必需的,而另一些可能会导致肌腱的损伤。目前研究表明机械负载、炎性因子影响腱细胞中基质金属蛋白的表达和活性,共同作用于腱细胞时具有协同或抑制效应。适当运动可使肌腱发生重塑,改善其力学性能、生化组成及结构。更多还原

【Abstract】 Metalloproteinases are a large family of enzymes capable of degrading all of the tendon matrix compo-nents,and these are thought to play a major role in the degradation of matrix during tendon remodeling.Some met-alloproteinase enzymes are required for the health of the tendon,and others may be damaging,leading to degenera-tion of the tissue.Now researches indicated mechanical loading and cytokines can regulate MMPs expression and activity,and there is a synergetic or inhibitory effect between them.Exercise leads to tendon remodeling,changing its biomechanical,biochemical and structural properties.更多还原