【摘要】 目的探讨急性髓系白血病(AML)免疫表型特征及其临床意义。方法采用流式细胞术(FCM)随机检测44例AML患者骨髓单个核细胞髓系和淋巴系免疫标志物,分析免疫标志物在AML的表达情况;根据淋巴系抗原髓系抗原的共表达情况,将AML分为淋巴系抗原阳性AML(Ly+AML)和淋巴系抗原阴性AML(Ly-AML),对二组AML采用统一方案化疗,比较二组AML化疗疗效。结果(1)44例AML中32例单纯表达髓系抗原,分别为CD13 86.4%,CD14 34.1%,CD15 36.4%。12例同时表达髓系、淋巴系抗原,其中,CD7+6例,CD10+2例,CD19+2例,CD3+1例,CD5+1例。(2)Ly+AML组的化疗的完全缓解率(CR)低于Ly-AML组(P<0.05)。结论免疫分型对于AL的分型诊断及其预后判断均有重要的指导意义。Ly+AML疗效差。更多还原

【Abstract】 Objective:To explore the immunophenotype characteristics and its clinical significance in acute myeloid leukemia(AML).Methods: Flow cytometry(FCM) was used to detect the bone marrow mononuclear cells(BMMNCs) of 44 patients with AML,and the antigens expression in AML was analyzed.The patients with AML were divided into the two groups: AML with positive lymphoid antigen(Ly+AML)and AML with negative expression of lymphoid antigen(Ly-AML), and all the cases were treated by unified protocol for chemotherapy,and then the difference in CR rate between the groups of Ly+AML and Ly-AML was analyed.Results:(1)Cases of AML expressed simply myeloid antigen with CD13 86.4%,CD14 34.1%,and CD15 36.4% respectively in 44 cases,12 cases of AML had co-expression of antigen from myeloid and lymphoid,with CD7+ 6 cases,CD10+ 2 cases,CD19+ 2 cases,CD3+ 1 case,CD5+ 1 case.(2)CR rate in Ly+AML was lower than that in Ly-AML(P<0.05).Conclusion: The immunophenotype of AML is useful for the diagnosis of patients with AML and for the assessment of prognosis of the patients.Ly+AML has poor prognosis.更多还原