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中药材辛夷挥发油GC-MS指纹图谱的建立

Quality Control of Volatile Oil of Magnolia. by GC-MS

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【作者】 何娟杨柳李艳福高会云刘德仓卢奎

【Author】 HE Juan,YANG Liu,LI Yan-fu,GAO Hui-yun,LIU De-cang,LU Kui(School of Chemistry and Chemical Engineering,Henan University of Technology,Zhengzhou 450052,China)

【机构】 河南工业大学化学化工学院河南工业大学化学化工学院 河南郑州450052河南郑州450052

【摘要】 通过对12个产地辛夷挥发油进行气相色谱-质谱联用分析,建立不同产地、不同采收期辛夷药材质量控制方法。通过计算机谱库检索,其主要成分为1,8-桉叶素、芳樟醇、α-松油醇、石竹烯、α-依兰油烯、西柏三烯、异合金欢醇,不同批次药材成分含量有一定的差别,不同产地及不同采收期样品间有较大差异。通过色谱峰的相对保留值α和量化的面积归一化值C i两个参数实现了从图谱形式到数字形式的转换,其重叠率除5、6号较低外(小于75%),其余都较高,在75%~90%之间,从指纹图谱中提取13强峰、特征指纹等信息,方法重复性RSD小于1.05%,样品在48 h内稳定。

【Abstract】 An analytical method for Magnolia.was established based on gas chromatography-mass spectrometry(GC-MS) and 12 batches of Magnolia.from different sources and/or collection time were analysed.The main components were eucalyptol,linalool,α-terpineol,caryophyllene,α-muurolene,duvatrien and farnesol isomer.There were some differences in constituents and contents among those samples.The chromatogram was transformed into chromatograph fingerprints by two parameters,the chromatographic peak relative retention value α and the area normalization value Ci.Overlapping rate were between 75%-90%,except No.5 and No.6,the first 13 strong peaks and feature fingerprint were obtained from the chromatographic fingerprints,RSD of reproducibility was less than 1.05% and the sample was stable for 48 h.

【基金】 郑州市科技攻关计划资助项目(064SGDG25127-8);河南工业大学博士基金资助项目;河南工业大学基金资助项目(0402011)
  • 【文献出处】 分析测试学报 ,Journal of Instrumental Analysis , 编辑部邮箱 ,2008年04期
  • 【分类号】R284
  • 【被引频次】24
  • 【下载频次】497
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