【摘要】 目的通过检测子宫内膜异位症(EMs)患者血清及腹腔液中血小板衍生生长因子(PDGF)、血管细胞粘附分子-(VCAM-1)浓度,探讨PDGF和VCAM-1在EMs发病中的作用。方法选取手术后病理证实为EMs的40例患者为EMs组,其中I~II期17例,III~IV23例;非EMs组20例作为对照组。应用酶联免疫吸附法(ELISA)检测血清及腹腔液中PDGF和VCAM-1水平。结果EMs组血清及腹腔液中PDGF、VCAM-1水平均明显高于对照组(P<0.01)。随EMs期别的增加,其血清和腹腔液中PDGF、VCAM-1含量呈上升趋势;EMsIII~IV期水平显著高于I~II期(P<0.05)。EMs患者PDGF与VCAM-1呈正相关性(P<0.05)。结论EMs患者PDGF、VCAM-1表达水平升高,在EMs的发生发展中具有重要作用。更多还原

【Abstract】 Objective:To detect the concentrations of platelet derived growth factor(PDGF),vascular cellular adhesion molecule-1(VCAM-1) in sera and peritoneal fluid of patients with endometriosis and study their possible role in the development of endometriosis.Methods: Forty patients with endometriosis pathologically diagnosed after operation were selected as endometriosis group,with 17 patients at stageI-II and 23 at stage III-IV.Twenty patients without endometriosis were as control.The levels of PDGF,VCAM-1 in their sera and peritoneal fluid were measured by the method of ELISA.Results: It was found that the expressions of both PDGF and VCAM-1 in patients with endometriosis were significantly higher than those in controls(P<0.01).The expression of PDGF,VCAM-1 in sera and peritoneal fluid correlated with the stage of the disease,with the higher levels of both PDGF and VCAM-1 at stage III-IV than at stageI-II(P<0.05).There was a positive correlation between PDGF and VCAM-1 levels in the patients with endometriosis(P<0.05). Conclusions:The expressions of PDGF and VCAM-1 are elevated in women with endometriosis,which may play an important role in the pathogenesis of endometriosis.更多还原