【摘要】 目的探讨头穴透刺结合中药清开灵(QKL)对急性脑出血(ICH)模型大鼠脑组织损伤的保护机制。方法采用脑内注入自体血凝块复制实验性脑出血大鼠模型,观察头穴透刺结合QKL注射液对模型大鼠第1天,3天及第7天时脑组织中内皮素(ET-1)和降钙素基因相关肽(CGRP)含量的影响。结果模型大鼠脑组织ET-1含量第1天升高,第3天尤著(P<0.01),第7天恢复;CGRP活性各天均显著降低(P<0.01)。结论头穴透刺结合QKL注射液具有调节ET-1和CGRP水平,从而改善脑血管的功能状态,可能是其治疗出血性中风的机理之一。更多还原

【Abstract】 Objective To explore the protection mechanism of scalp-acupunctrure conbimed with Qimgkailing injection on acute intracerebral hemorrhage rats.Methods We dupliacated the intracerebral hemorrhage model of rat by injecting autoblood colt into brain,and brain tissue endothelin and calcitonin gene-related peptide contents were determined on the 1st,3rd,7th days after making the model.Results The content of brain tissue endothelin was increased on the 1st day,and obviously on the 3rd day(P<0.01),however,it was to normal level on the 7st day,the content of brain tissue calcitonin content gene-related peptide was decreased obviously on the 1st,3rd,7th days(P<0.01).Conclusion Scalp-acupuncture and injecting"Qingkailing" injection can adjust the contents of brain tissue endothelin and calcitonin,improve the functional status of Cerebrovascular tissue,which may be the possible mechanism of treating intracerebral hemorrhage.更多还原