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山梨猕猴桃根提取物抗肿瘤活性研究

Study on the Anti-tumor Active Components Extracted from Roots of Actinidia rufa Planch

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【Author】 LIN Guo-biao1,ZHANG Wen-yan1,ZHANG Feng-fen1,CHEN Xi-hui2,HUANG Chu-sheng3,ZHONG Zhen-guo1* (1.Guangxi University of Traditional Chinese Medicine,Nanning 530001,China;2.Chemical College of Guangxi University,Nanning 530004,China;3.Guangxi Normal College 530023,China)

【机构】广西中医学院；广西大学化学化工学院；广西师范学院；广西中医学院广西南宁530001；广西南宁530001；广西南宁530004；广西南宁530023；

【摘要】目的从山梨猕猴桃根中筛选抗肿瘤活性成分。方法采用MTT法、细胞集落形成法筛选山梨猕猴桃根提取物的抗肿瘤活性成分。结果山梨猕猴桃根提取物用集落形成法R6,R8对胃癌细胞株SGC7901、白血病细胞株L1210、神经性肿瘤细胞株NG108-15、肝癌细胞株Bele7404的增殖有抑制作用;用MTT法对NG108-15,SGC7901的增殖有抑制作用。山梨猕猴桃根两种提取物(R6,R8)对脾淋巴细胞没有免疫毒性。结论山梨猕猴桃根提物R6,R8有抗肿瘤活性。更多还原

【Abstract】 Objective To screen the anti-tumor active components extracted from roots of A.rufa Planch.Methods The anti-tumor activity of the components extracted from roots of A.rufa Planch was determined by MTT and clone cells assay.Results R6,R8 extracted from roots of A.rufa Planch could restrain the cell proliferation in the stomach carcinoma SGC7901,lymphocytic leukemia L1210,mouse neuroblastomax rat gliom hybrid NG108-15,and human hepatocellular carcinoma Bele7404 cell strain by clone cells and restrain the cell SGC7901,NG108-15 cell strain by MTT.2 kinds of extracts(R6,R8) had no immunity toxicity to the lymphocyte in spleen.Conclusion The results show that R6,R8 extracted from roots of A.rufa Planch have the anti-tumor activity.更多还原

【关键词】山梨猕猴桃根提取物；抗肿瘤活性成分筛选；肿瘤细胞株；
【Key words】 The active components extracted from Roots of A.rufa Planch； Screening of the anti-tumor activie components； Tumor cell strain；

【基金】国家自然科学基金地区联合资助项目(No.30160095);广西高校人才小高地建设创新团队资助计划

【文献出处】时珍国医国药 ,Lishizhen Medicine and Materia Medica Research , 编辑部邮箱 ,2008年03期

【分类号】R285
【被引频次】6
【下载频次】352

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