Objective To evaluate the efficacy of recombinant adenovirus p53 (rAd-p53) therapy for advanced hepatocellular carcinoma and its effect on quality of life in those patients. Methods From October 2003 to October 2006, 69 patients were assigned to receive gene therapy (39 patients, rAd-p53 solution at a dose of 1×or 2×1012 VP weekly for 4 or 8 weeks), or conventional nutritional therapy (30 patients). Quality of life was measured in each patient with the Quality of Life Scale. Results As compared with those r...
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