【摘要】 目的:探讨白细胞介素6(IL-6)和白细胞介素18(IL-18)血清水平与类风湿性关节炎(RA)中医辨证分型的关系。方法:采用酶联免疫吸附试验(ELISA)双抗体夹心法检测RA患者和健康人的外周血IL-6和IL-18的血清水平,分析不同证型两指标之间及其与C反应蛋白、类风湿因子含量的相关性。结果:RA患者IL-6和IL-18血清水平与健康人比较差异具有显著性,活动期RA患者IL-6水平显著高于稳定期患者(P<0.05)。风寒湿阻型患者血清IL-6浓度明显高于痰瘀互结型与肝肾两虚型(P<0.05),而与风湿热郁型无明显差异(P>0.05);而风寒湿阻型患者血清IL-18浓度明显高于风湿热郁型与肝肾两虚型(P<0.05),而与痰瘀互结型无明显差异(P>0.05)。结论:IL-6血清水平与RA的活动性密切相关,且与其中医辨证分型存在一定的联系。更多还原

【Abstract】 Objective To study the relationship between interleukin-6(IL-6) and interleukin-18(IL-18) levels in serum and the syndrome differentiation of rheumatoid arthritis(RA). Methods The enzyme linked immunosorbent assay (ELISA) was used to measure IL-6 and IL-18 levels in serum of RA patients and healthy controls. Results The IL-6 and IL-18 levels in serum of RA patients were significantly higher than that of healthy controls(P < 0.05). IL-6 level in patients with RA of cold and moist hinder type was significantly higher than that of sputum and silt hinder type and lung-kidney dual vaccity type (P < 0.05),and IL-18 level in patients with RA of cold and moist hinder type was significantly higher than that of moist and heat gloomy type and lung-kidney dual vaccity type (P < 0.05). Conclusions The high level of IL-6 in serum is helpful for diagnosis of RA and estimating disease activity. There is correlation between serum level of IL-6 and the the syndrome patterns of RA.更多还原