【摘要】 目的:探索pH、CEA、CA-199联合检测对鉴别良、恶性胸腹水的意义。方法:选取良性及恶性肿瘤患者,同时抽取胸腹水和静脉血,采用ELISA法检测血清及胸腹水中CEA、CA-199,pH计测定胸腹水pH值。结果:恶性组患者胸腹水CEA、CA-199水平高于相应血清值,差异具有统计学意义(P<0.01)。恶性组与良性组血清与胸腹水CEA、CA-199含量相比差异亦有显著性(P<0.01),而良性疾病组血清与相应胸腹水间CEA、CA-199含量差异无显著性。恶性肿瘤组pH值偏碱(6.9~9.2)。恶性组CEA检测阳性率为93.3%,CA-199检测阳性率为88.9%,联合pH检测阳性率为100%。结论:联合检测pH、CEA、CA-199等指标有利于良、恶性肿瘤的鉴别诊断。更多还原

【Abstract】 ObjectiveTo explore the significance of combined detection of pH、CEA and CA-199 for the distinguishing diagnosis of carcinoid and malignant pleural /ascitic fluid. MethodsPleural/ascitic fluid and vein blood were extracted from benign and malignant tumors respectively and CEA, CA-199 were detected by ELISA. ResultsThe level of CEA、CA-199 in malignant pleural/ascitic fluid was higher than that in serum(P<0.01), there was significant difference of CEA、CA-199 in serum and pleural/ascitic fluid between carcinoid and malignant tumor(P<0.01). There was no significant difference between serum and pleural/ascitic of carcinoid. pH of malignant tumors was higher and positive rate of CEA and CA-199 were 93.3% and 88.9%, while the positive rate of combined detection was 100%. ConclusionCombined detection of pH、CEA and CA-199 may be a useful method for the distinguishing diagnosis of carcinoid and malignant tumors.更多还原