【摘要】 目的为寻找半红树植物阔苞菊[Pluchea indica(L.)Less.]不同于陆生植物的次生代谢产物及民间治疗瘰疬(淋巴腺结核)的物质基础,对其进行化学成分的研究。方法采用硅胶、SephadexLH-20、HPLC等色谱方法进行分离纯化,通过理化性质、波谱方法以及结合文献对照鉴定结构。结果从阔苞菊体积分数为90%的乙醇提取物的乙酸乙酯部分分离并鉴定了3个噻吩类衍生物及3个倍半萜类化合物,分别为:2-(1,3-戊二炔)-5-(4-乙酰氧基-3-羟基-1-丁炔)-噻吩[2-(pant-1,3-diynyl)-5-(4-acetoxy-3-hydroxybuta-1-ynyl)-thiophene,1]、2-(1,3-戊二炔)-5-(4-乙酰氧基-3-氯-1-丁炔)-噻吩[2-(pant-1,3-diynyl)-5-(4-acetoxy-3-chlorobuta-1-ynyl)-thio-phene,2]、2-(1,3-戊二炔)-5-(3、4-二羟基-1-丁炔)-噻吩[2-(pant-1,3-diynyl)-5-(3,4-dihydroxybuta-1-ynyl)-thiophene,3]、8,11-二羟基-1(10)-瓦伦烯[valenc-1(10)-ene-8,11-diol,4]、2,8,11-三羟基-1(10)-瓦伦烯[valenc-1(10)-ene-2,8,11-triol,5]、5-氧代-5,6-氢-希菲比尔醇[5-oxo-5,6-H-silphiperfolen,6]。结论化合物2-6均为首次从该种植物中获得。更多还原

【Abstract】 Objective To investigate the chemical constituents of the stems and leaves of Pluchea indica(L.)Less..Methods The compounds were isolated by silica gel chromatography column in associating with Sephadex LH-20 and HPLC chromatography.Their structures were elucidated by spectroscopic analysis.Results Six compounds,including three sesquiterpenes and three thiopene derivatives,were obtained.Their structures were identified as 2-(pant1,3-diynyl)-5-(4-acetoxy-3-hydroxybuta-1-ynyl)-thiophene(1),2-(pant-1,3-diynyl)-5-(4-acetoxy-3-chlorobuta-1-ynyl)-thiophene(2),2-(pant-1,3-diynyl)-5-(3,4-dihydroxybuta-1-ynyl)-thiophene(3),valenc-1(10)-ene-8,11-diol(4),valenc-1(10)-ene-2,8,11-triol(5),1,2,4,8-tetramethyl-(4R,7S,8R,11R)-3-cycloundecenone(6).Conclusions Compounds 26 are isolated from Pluchea indica(L.)Less.for the first time.更多还原