【摘要】 目的研究黄花蒿(Artemisia annuaL.)全草的化学成分。方法用硅胶、聚酰胺和SephadexLH-20柱色谱分离化合物,根据理化性质和波谱数据鉴定其结构。结果从黄花蒿全草的乙醇提取物中分离得到13个化合物,分别鉴定为:青蒿素(artemisinin,1)、青蒿乙素(arteannuin B,2)、3α-羟基-1-去氧青蒿素(3α-hydroxy-1-deoxyartemisinin,3)、青蒿酸(artemisinic acid,4)、artemetin(5)、猫眼草黄素(chrysosplenetin,6)、quercetagetin-3,7,3′,4′-tetramethyl ether(7)、猫眼草酚(chrysosplenol D,8)、水杨酸(salicylic acid,9)、domesticoside(10)、东莨菪苷(scopolin,11)、β-谷甾醇(β-sitosterol,12)、胡萝卜苷(daucostrol,13)。结论化合物1-4为同一类化合物,属倍半萜类,化合物5-8为具有多甲氧基取代的黄酮类化合物,化合物10为首次从菊科植物中分离得到。更多还原

【Abstract】 Objective To study chemical constituents from the the leaves of Artemisia annua.Methods Compounds were isolated and purified by column chromatography over Sephadax LH-20 and silica gel column.Their chemical structures were elucidated on the basis of physicochemical properties and spectral data.Results Thirteen compounds were isolated,purified,and identified as:artemisinin(1),arteannuin B(2),3α-hydroxy-1-deoxyartemisinin(3),artemisinic acid(4),artemetin(5),chrysosplenetin(6),quercetagetin-3,7,3′,4′-tetramethyl ether(7),chrysosplenol D(5,3′,4′-trihydroxy-3,6,7-trimethoxyflavone,8),salicylic acid(9),domesticoside(2-O-βD-glucopyranosyl-4-O-methyl phloracetophenone,10),scopolin(11),β-sitosterol(12),daucostrol(13).Conclusions Compounds 14 belong to biosynthetic related sesquiterpenoid,and compound 10 is isolated from the Compositae family for the first time.更多还原