【摘要】 目的探讨不同化疗方案联合放疗治疗局部晚期鼻咽癌的疗效。方法80例Ⅲ、Ⅳa期鼻咽部低分化鳞癌患者,随机分为研究组和对照组两组,每组40例。研究组用泰索帝(TXT)+草酸铂(L-OHP)化疗结合放疗;对照组用顺铂(DDP)+甲酰四氢叶酸钙(CF)+5-氟脲嘧啶(5-Fu)化疗结合放疗。放疗为根治性,化疗4～5个周期,每3周为1个周期。结果两组鼻咽部原发灶及颈部淋巴结消退情况相似,差异无统计学意义(P>0.05),但研究组恶心呕吐及黏膜反应的发生率明显低于对照组,差异有统计学意义(P<0.05)。结论TXT+L-OHP方案联合放疗治疗晚期鼻咽癌的近期疗效与DDP+CF+5-Fu方案相似,但不良反应明显减少。更多还原

【Abstract】 Objective To investigate the efficacy of radiotherapy combined with chemotherapy of different regimen in the treatment of loca-advanced nasopharyngeal carcinoma(NPC).Methods Eighty patients with loco-advanced NPC(grade Ⅲ、Ⅳa) were divided into two groups randomly,each 40 cases.One was the research group treated by Taxotere(TXT) plus Oxaliplatin(L-OHP)combined with radiotherapy.The other was the control group delivered with Cisplatin(DDP)plus Cetrovorum factor(CF) and Fluorouracil(5-Fu) combined with radiotherapy.Radiation was radical and chemotherapy was presented 4~5 cycles,one cycle every 3 weeks.Results The occurrences of nausea and vomiting or mucositis in the research group were less than those in the control group significantly(P<0.05).The regressions of nasopharyngeal primary sites and Lymph nodes of neck were similar between two groups(P>0.05).Conclusions The regimen of TXT+L-OHP combined with radiotherapy is superior to DDP+CF+5-Fu plus radiotherapy in the treatment of loca-advanced NPC with similar short-term effects and less complications.更多还原