【摘要】 目的观察微泵注射普通肝素治疗急性期脑梗死的疗效和安全性。方法将186例脑梗死住院患者随机分为微泵注射普通肝素组和对照组。入院后2组根据病情给予脱水剂、神经保护剂、阿司匹林等治疗,肝素组同时立即给予微泵注射普通肝素(4.25~8.50U/min)治疗,观察比较2组临床神经功能缺损改善情况及微泵注射普通肝素的安全性。结果治疗组显效率和总有效率较对照组(分别为43.3%vs21.2%,P<0.001;93.4%vs54.6%,P<0.001)差异有统计学意义,治疗组神经功能缺损评分(10.80±4.02vs15.20±3.43,P<0.01)明显低于对照组,2组均无出血并发症发生。结论微泵注射普通肝素能明显改善急性期脑梗死临床神经功能缺损并且安全有效。更多还原

【Abstract】 Objective To investigate the effect and safety of ordinary heparin injected by micro-injection pump for acute cerebral infarction.Methods 186 cases of cerebral infarction patients were randomly divided into micro-injection pump unfractionated heparin group and the control group.All patients were treated with dehydrating agent,neuroprotective agents,aspirin,and so on.Unfractionated heparin were injected by micro-injection pump (4.25～8.50 U/min).Clinical neurological defect and safety of heparin injected by micro-injection pump were compared between two groups.Results Significantly efficiency and total efficiency of treatment group were better than control group (43.3% vs 21.2%,P<0.001;93.4% vs 54.6%,P<0.001),neurological functional scores of treatment group (10.80±4.02 Vs 15.20±3.43,P<0.01) were significantly lower than that of control group.There were no bleeding complications occurred.Conclusions Injection of unfractionated heparin by micro-injection pump is safe and can improve neurological function of patients with acute cerebral infarction.更多还原