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牛磺酸对大鼠血压及相关因子的影响
Effect of Taurine on Blood Pressure and the Vasoactive Substance Concerning Hypertension in Rats
【摘要】 通过检测补充不同水平牛磺酸和-β丙氨酸(牛磺酸转运抑制剂)大鼠的血压和心肌中环一磷酸腺苷(Cyclic 3’,5’-adenosine monophosphate,cAMP)、环一磷酸鸟苷(cyclic 3’,5’-guanosine monophosphate,cGMP)和血清中Ca2+和Na+的含量,探讨牛磺酸对高血压发生的预防作用。试验结果表明:补充牛磺酸可使大鼠尾部动脉血压降低的同时,心肌中cGMP的含量提高44.2%(p<0.05),而对心肌中cAMP和血清Ca2+、Na+的含量变化均不显著(p>0.05)
【Abstract】 Different levels of taurine and β-alanine were added to deterrmine the blood pressure,the content of cAMP and cGMP in ardiac muscle,and the contents of Ca2+;Na+ in the serum.The results indicated that taurine reduced the tail arterial blood pressure,meanwhile increased the content of cGMP 44.2%(p<0.05),but no significant differences were found in the level of cAMP;Ca2+ and Na+(p>0.05).
【基金】 国家自然科学基金项目(30471263);辽宁省科学技术基金项目(2040488)
- 【文献出处】 沈阳农业大学学报 ,Journal of Shenyang Agricultural University , 编辑部邮箱 ,2008年03期
- 【分类号】R285.5
- 【被引频次】3
- 【下载频次】138