【摘要】 以偏三甲苯为原料,HCl-H2O2-CH3COOH为催化活化体系,一步法合成1-氯-2,4,5-三甲基苯,通过正交实验,考察了影响反应的各种因素,确定了反应的最佳条件:温度为60℃,H2O2与偏三甲苯(TMB)的摩尔比为4.5,HCl与TMB的摩尔比为4:1,进料完全后反应时间为2h,在此条件下反应的原料转化率为98.4%,产品收率为82.8%,纯度为99%。更多还原

【Abstract】 1-Chloro-2,4,5-trimethyl-benzene was synthesized by one-step method,unsym-trimethylbenzene as the raw material,while HCl-H2O2-CH3COOH as the catalytic activity system.By the orthorhombic experiment,the influenced factors are considered and the optimum conditions are confirmed.The experiment was carried under 60℃ for 2 h,while the mole ratio of H2O2 and unsym-trimethylbenzene is 4.5,HCl and unsym-trimethylbenzene is 4.0.The average yield was 82.8%,and the conversion rate was 98.4% while the fineness 99% under those conditions.更多还原