【摘要】 目的研究黄体酮-平阳霉素乳剂在子宫肌瘤介入治疗中的临床疗效及副反应。方法随机将110例子宫肌瘤患者分为聚乙烯醇微粒和黄体酮-平阳霉素乳剂栓塞2组。采用Seldinger技术,经皮穿刺行双侧子宫动脉插管,注入黄体酮-平阳霉素乳剂或聚乙烯醇微粒阻断子宫肌瘤血供。治疗前后均用B超测量子宫肌瘤体积,并观察术后各种反应和月经量变化。结果2组患者月经量恢复正常和明显减少,总有效率为95.49%;术后3个月和6个月肌瘤体积较治疗前缩小45.81%和51.80%。与治疗前比较有显著差异(P<0.01)。2组在月经量改变和子宫肌瘤体积变化上比较无显著差异。术后发热及缺血性盆腔疼痛为2组的主要副反应,无严重并发症。结论使用黄体酮-平阳霉素乳剂栓塞子宫动脉治疗子宫肌瘤,创伤小、疗效好、副作用小。黄体酮-平阳霉素乳剂是一种经济有效的新型栓塞剂。更多还原

【Abstract】 Objective To research the clinical therapeutic effect and side effect of gesterol- pingyangmycin cream in interventional therapy of hysteromyoma. Methods 110 cases of hysteromyoma underwent interventional therapy who were divided randomly into two groups:group A with polyvinyl alcohol particle and group B with gesterol-pingyangmycin cream .By percutaneous catheterization in bilateral uterine arteriae using the technique of Seldinger,polyvinyl alcohol particle or gesterol-pingyangmyci cream were injected to blodk up the blood supply of hysteromyoma.The volume of hysteromyomas was measured with B-mode ultrasonography prior and post-treatment.The reaction of post-treatment and the changes of menstrual blood volume were observed . Results The menstruation turned to normal and or menstrual blood volume reduced obviously in two groups , the total effective rate was 95.49 . The volume of hysteromyomas diminished to 45.81 and 51.80 in 3 and 6 months,respectively after treatment.There was significant difference between prior and post-treatment(P<0.01),but there was no significant difference in the changes of menstrual blood volume and hysteromyoma volume between prior or post-treatment.The side effects were fever and ischemic cavitas pelvis pain after operation.There were not serious complications.Conclusion The interventional therapy of hysteromyomas using gesterol-pingyangmycin cream to embolism uterine artery has mini-trauma,good curative effect,few side effect.Gesterol-pingyangmycin cream is a new economical and effective embolized agent.更多还原