【摘要】 目的:探讨盐酸消旋山莨菪碱预防乳腺癌术后皮瓣坏死的作用。方法:对312例乳腺癌改良根治术后患者随机分为两组,A组为实验组采用消旋山莨菪碱20mg/kg+0.9%氯化钠注射液50m l微量每日泵静推,B组采用常规方式治疗,比较两组切口皮瓣愈合情况。结果:A组176例中皮瓣坏死22例(12.5%)B组136例皮瓣坏死36例(26.4%),横行切口和纵行手术切口均显示用盐酸消旋山莨菪碱可降低皮瓣坏死率。结论:手术是发生皮瓣坏死的危险因素,纵切口发生皮瓣坏死的风险更大,应用盐酸消旋山莨菪碱可使乳腺癌术后皮瓣坏死率降低。更多还原

【Abstract】 Objective:To approach the effect of Racanisodamine in the preservation of flap necrosis after breast surgery.Methods: To divide randomly 312 patients with modified radical mastectomy into two goups.The patients in group A were administrated racanisodamine 20mg/kg and 0.9% sodium chloride through micro pump every day as experimental group,and those in group B were treated with common mathad as control group.Both two groups included patients operated with transverse or longitudinal incision.Compared the incidence of flap necrosis between 2 groups.Results: There were 22 cases apearing flap necrosis among 176 cases of group A(12.5%),while 36 cases apeared flap necrosis among 136 cases of group B(26.4%).No matter which kind of incision were applied,the incidence of flap necrosis was lower in experimental group than control group and the difference was statistically significant(P<0.05).In respective groups,the incidence of flap necrosis was lower in the patients applied transverse incision than longitudinal incision but the difference was not statistically significant(P>0.05).Conclusion: Racanisodamine is a protective factor of flap necrosis.Longitudinal incision is tend to lead to flap necrosis.更多还原