【摘要】 目的:观察恶性肿瘤患者血清骨钙素(OC)、甲状旁腺素(PTH)的含量变化与骨转移发生、发展的关系。方法:放射免疫检测恶性肿瘤患者70例和正常健康人30例血清OC和PTH水平。结果:OC水平骨转移组高于正常对照组(P<0.02),非骨转移组低于正常对照组(P<0.01),骨转移组明显高于非骨转移组(P<0.001),PTH水平骨转移组高于正常对照组(P<0.01),非转移组与正常对照组比较无明显变化(P>0.05),骨转移组明显高于非骨转移组(P<0.01)。骨转移组转移病灶的数量与OC、PTH的含量成正相关。结论:血清OC、PTH对骨转移诊断具有一定临床价值。更多还原

【Abstract】 Objective:To observe the relationship between the levels of serum osteocalcin(OC) and parathormone (PTH) and the bone metastasis in patients with malignant tumor.Methods:Radioimmunity assay was used to detect the levels of serum OC and PTH in 70 patients with malignant tumor and 30 normal controls.Results:The levels of serum OC were higher in patients with bone metastasis than those in controls (P<0.02),while the levels were lower in patients without bone metastasis than those in controls(P<0.01).Compared with those in no bone metastasis group,The levels of serum OC increased significantly in bone metastasis group(P<0.001).The levels of serum PTH in patients with bone metastasis were higher than those in controls (P<0.01),there was no statistical differences in the levels of serum PTH between no bone metastasis group and the control group(P>0.05).The levels remarkablely higher in patients with bone metastasis than those without bone metastasis (P<0.01).Positive correlation was found between the number of diffusing lesions and the concentration of OC and PTH.Conclusion:The detection of the levels of serum OC and PTH can be valuabele for diagnosis of bone metastasis in patients with malignant tumor.更多还原