【摘要】 目的:报道1例急性部分分化型髓系白血病(AML-M2a)患者化疗后发生肝、脾真菌感染(hepato-splenic fungal infection,HSF)及其治疗经过,并进行文献复习。方法:我院2001年收治1例AML-M2a患者,化疗后发生HSF,先后给予两性霉素B、氟康唑、大蒜油、伊曲康唑及各种抗生素联合治疗,并行脾切除术。结果:经过上述治疗,无法控制侵袭性真菌感染,但患者至今仍存活并继续治疗。结论:HSF早期诊断和治疗困难,病死率高,需采取预防措施,手术切除感染灶对于延长生存期可能是有效的。更多还原

【Abstract】 Objective:To report a case hepatosplenic fungal infection(HSF)after chemotherapy and the treatment outcome.Methods:A patient with acute non-lymphoblastic leukemia(M2a)occurred HSF after chemotherapy and was treated with amphotericin B(AmB),fluconazole,garlicin,itraconazole and several antibiotics and splenectomy.Results:Though the invasive fungal infection has been uncontrolled,the patient is still alive and is being treated.Conclusion:It is difficult to diagnose early and treat HSF.It should be prevented because its high case fatality.It is possibly effective to prolong life span with surgical excision.更多还原