【摘要】 目的:检测乳腺癌组织中雌激素受体β(ERβ)、C-erbB-2和bcl-2蛋白的表达情况,并分析ERβ蛋白的表达与组织学分级、C-erbB-2及bcl-2蛋白表达的关系。方法:采用免疫组化S-P法检测96例乳腺癌组织标本中ERβ、C-erbB-2及bcl-2蛋白的表达情况,并作统计学分析。结果:96例乳腺癌组织标本中,ERβ、C-erbB-2及bcl-2蛋白阳性表达率分别为64.6%、36.5%和51.0%;ERβ蛋白的表达与组织学分级、C-erbB-2蛋白的表达呈负相关(P<0.05),与bcl-2蛋白的表达呈正相关,与腋淋巴结状态无关(P>0.05)。结论:ERβ蛋白表达可能是乳腺癌患者预后良好的指标。更多还原

【Abstract】 Objective:To detect the expressions of ERβ,C-erbB-2 and bcl-2 protein in breast cancer,and analyze the relationship between the expression of ERβ protein and tumor grade,the expression of C-erbB-2 and bcl-2 protein.Methods:Immunohistochemistry S-P method was used to detect the expression of ERβ,C-erbB-2 and bcl-2 protein in 96 breast cancer samples.Rssult of detection were analyzed statistically.Results:The positive expression rates of ERβ,C-erbB-2 and bcl-2 protein were 64.6%,36.5% and 51.0% respectively;The expression of ERβ protein had a negtive correlation with tumor grade and the expression of C-erbB-2 protein(P<0.05),and had a positive correlation with the expression of bcl-2 protein,no correlation with axillary lymph node status(P>0.05).Conclusion:ERβ protein may be a useful marker which predicts good prognosis of breast cancer patients.更多还原