【摘要】 目的研究抑制素、表皮生长因子受体在人卵巢颗粒细胞瘤中的表达及临床意义。方法选取37例经病理医师诊断为卵巢颗粒细胞瘤的石蜡切片,用免疫组织化学法检测其中的抑制素、表皮生长因子受体表达的变化,并与正常对照组比较。结果抑制素和表皮生长因子受体在卵巢颗粒细胞瘤组的表达率分别为70.27%和64.86%,在正常组的表达率分别为20.00%和20.00%,两组间比较差异有统计学意义(P<0.05)。结论人卵巢颗粒细胞瘤中抑制素、表皮生长因子受体表达明显增高,对提高卵巢颗粒细胞瘤诊断及预测其预后具有重要意义。更多还原

【Abstract】 Objective To investigate the expression of inhibin,epidermal growth factor receptor in human ovarian granulosa cell tumor and their clinical significance. Methods The paraffin sections from 37 patients diagnosed as ovarian granulosa cell tumor were collected.Expression of inhibin and epidermal growth factor receptor was measured with immunohistochemistry. Results The expression rates of inhibin and epidermal growth factor receptor in ovarian granulosa cell tumor were 70.27% and 64.86%,while they were 20.00% and 20.00% in normal ovarian tissues,and there was significant difference between two groups(P<0.05). Conclusion The results indicate that inhibin and epidermal growth factor receptor could be used for diagnosis of ovarian granulosa cell tumor and prediction of prognosis.更多还原