【摘要】 利用溶剂挥发成膜法制备了负载9-硝基喜树碱(9-NC)的两亲性共聚物载药胶束。通过对制备温度、加入蒸馏水体积、搅拌速率和投药量的单因素分析,深入探讨了各因素对胶束粒径和载药量的影响。结果表明在水浴温度为60℃、加入蒸馏水体积为16 ml、搅拌速率为6 500 r/min、投药量为1.2 mg时制备得到具有良好分散状态的球状载药胶束,载药量为4.9%,粒径为50~70 nm。载药胶束的体外释放研究表明,9-NC从胶束中释放包括初期爆释和随后缓释两个阶段,释放速率随载药量的增加而降低。更多还原

【Abstract】 9-nitro camptothecin(9-NC) loaded amphiphilic copolymer micelles were prepared with solvent evaporation method.The effects of temperature,distilled water volume,stirring rate,and drug input amount on the size and drug content of micelles were further discussed.As a result,well dispersed spherical micelles with drug content of 4.9 percent and 50～70 nanometers in diameter were achieved with the following preparation conditions: water bath temperature 60℃,distilled water amount 16 ml,stirring rate 6 500 r/min,and drug input amount 1.2 mg.9-NC release profiles in vitro illustrated that drug release from micelles included initial burst release and following controlled release.The release rate was decreased with the increase of drug content.更多还原