【摘要】 动脉粥样硬化(atherosclerosis,As)是一种炎症性病变,它以血管壁上巨噬细胞源性的泡沫细胞和大量趋化因子、细胞因子和生长因子堆积为主要特征。这些因子调节着固有细胞的迁移、分化和转归,最终影响动脉粥样硬化斑块形成,其中一个关键的调节因子就是转录因子核因子-κB(NF-κB)。过去它都被一直认为是一个促进动脉粥样硬化的因子,主要是由于它调节许多与动脉粥样硬化有关促炎基因的表达。最近有文献报道说NF-κB有可能在促炎、抗炎、细胞的生存和增值方面巧妙地监护着动脉粥样硬化过程的平衡。因此,本文就NF-κB与动脉粥样硬化病变有关的启动、泡沫细胞的形成、炎症、免疫、平滑肌细胞增值、纤维帽形成、细胞凋亡关系的新进展作一综述。更多还原

【Abstract】 Atherosclerosis is an inflammatory disease,characterized by the accumulation of macrophage-derived foam cells in the vessel wall and a lot of chemokines,cytokines and growth factors.These factors regulate migration,differentiation and prognosis of resident cells,eventually influencing plaque development,in which,one of the key regulators is the transcription factor nuclear factor-KB (NF-κB),which had been always regarded as a proatherogenic factor for it regulated the expression of many pro-inflammatory genes related to atherosclerosis.Recently,some literature reported that NF-κB might skillfully monitor the balance of atherosclerotic process in pro-inflammation,anti-inflammation,survival and proliferation of cells.So,this paper will review new progress on the relations between NF-κB and the starting,the formation of foam cells,inflammation,immunity,the proliferation of smooth muscle cells,the formation of fibrous cap related to atherosclerosis.更多还原