【摘要】 在纤维素-三(3,5-二甲基苯基氨基甲酸酯)(CDMPC)手性固定相上,分别采用正相、反相及极性有机相色谱模式对氟环唑外消旋体进行了拆分,并考察了流动相组成在手性识别中对手性分离的影响。氟环唑在Chiralcel OD-H手性色谱柱(填充CDMPC手性固定相)上采用反相色谱模式,以甲醇-水(体积比为80∶20)为流动相,获得了最佳的拆分,其两对对映异构体的分离度Rs分别为1.64和6.50。更多还原

【Abstract】 The two pairs of enantiomers of epoxiconazole were resolved using normal phase,reversed-phase and polar organic solvent high performance liquid chromatography on cellulose tris(3,5-dimethylphenylcarbamate)(CDMPC)chiral stationary phase,separately.The effects of different mobile phase compositions on the retention factor,separation factor and resolution in the chiral separation of epoxiconazole were investigated.It can be baseline separated on a Chiralcel OD-H column packed with CDMPC chiral stationary phase when methanol-water(80∶20,v/v)was used as the mobile phase,the resolutions of the two pairs of enantiomers were 1.64 and 6.50,respectively.更多还原