【摘要】 目的探讨参附注射液对老年血管性痴呆病人认知功能的影响及应用的安全性。方法将93例老年血管性痴呆病人随机分为治疗组(47例)和对照组(46例)。对照组用生理盐水注射液250 mL加胞二磷胆碱注射液0.75 mL静脉注射,每日1次。治疗组在对照组用药的基础上联用生理盐水注射液250 mL加参附注射液40 mL静脉注射,每日1次。两组均以3周为1疗程。治疗前后采用简易智能状态量表(MMSE)和日常生活能力量表(ADL)评价临床疗效。结果治疗组1例失访,对照组3例失访。治疗后治疗组MMSE和ADL评分显著优于对照组(t=2.66、7.79,P<0.01)。结论参附注射液治疗老年血管性痴呆安全性好,能改善病人的认知功能,提高生活质量。更多还原

【Abstract】 Objective To observe the efficacy and safety of Shenfu injection in the treatment of cognitive function in the elderly with vascular dementia. Methods Ninety-three patients with vascular dementia were randomized to treated group(n=47),Shenfu injection 40 mL in normal saline 250 mL;and control group(n=46),Citicoline injection 0.75 mL in normal saline 250 mL.The medications were give intravenously,once a day for three weeks for both groups.The efficacy was evaluated by using mini-mental state examination(MMSE) and activities of daily living(ADL) before and after treatment. Results One patient in treated group and three patients in control group failed to follow.MMSE and ADL scores in the treated group were superior to the control after treatment(t=2.66,7.79;P<0.01). Conclusion Shenfu injection is safe and effective for patients with vascular dementia,which improves patients’ cognition and quality of life.更多还原