【摘要】 目的尝试并评价口服氨甲环酸治疗黄褐斑的新方法。方法使用低剂量的氨甲环酸对256例黄褐斑患者行长时间口服,服药时间6～15个月,平均9.6个月。观察服药后的临床效果、疗效出现时间、复发情况及不良反应等。结果治疗后随访256例患者3～5个月,80.9%的患者出现了不同程度的色斑减退。65.0%的患者服药后2个月色斑开始减轻,35.0%的患者服药后1个月出现效果。服药6个月后基本治愈、明显消退和好转者分别为10.5%、18.8%和51.6%。停药后复发者21例(8.2%)。除11例(4.3%)患者出现轻度胃肠道反应、9例(3.5%)患者出现月经量减少以外,未发现其他明显的不良反应。结论低剂量长时间口服氨甲环酸是一种安全有效治疗黄褐斑的新方法。更多还原

【Abstract】 Objective To evaluate the clinical application and effects of oral tranexamic acid as a novel therapy for the treatment of melasma.Methods Two hundred and fifty-six patients with melasma were treated with oral administration of tranexamic acid using lower dosage over a long term.The treatment period was 6～15 months(mean 9.6 months).A retrospective study was made on the therapeutic effect and safety.Results The patients were followed for 3～6 months after treatment.The total improvement rate was 80.9%.Many patients(65.0%) showed clinical effect at the second months of treatment,however 35.0% showed an effect in the first month of treatment.After 6 months’ treatment,the percentages of patients who were basically cured,or had excellent or good results were 10.5%,18.8% and 51.6%,respectively.Twenty-one patients had recurrences(8.2%).There were no obvious side effects of the treatment except a gastrointestinal reaction in 11 patients(4.3%) and hypomenorrhea in 9 patients(3.5%).Conclusion Oral administration of tranexamic acid with a Relatively low dose over a long term is a novel therapy,which is safe and effective in the treatment of melasma.更多还原