【摘要】 目的探讨非酒精性脂肪肝患者非高密度脂蛋白胆固醇(non-HDL-C)水平及临床应用价值。方法检测973名职工缝康体检者的总蛋白(TP)、白蛋白(Alb)、球蛋白(Glo)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBil)、直接胆红素(DBil)、间接胆红素(IBil)、葡萄糖(Glu)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A-Ⅰ(apo A-Ⅰ)、载脂蛋白B(apo B),计算non-HDL-C及apo B/apo A-Ⅰ、LDL-C/HDL-C、apo B/HDL-C、TC/HDL-C比值,并对其中89例非酒精性脂肪肝与202名体检健康者进行比较。结果脂肪肝检出率为9.15%,男性检出率为12.50%,显著高于女性的5.99%(P<0.05);与对照组比较,59例男性患者的ALT、IBil、TG、HDL-C、LDL-C、apo A-Ⅰ、non-HDL-C水平及apo B/apo A-Ⅰ、LDL-C/HDL-C、apo B/HDL-C、TC/HDL-C比值差异具有统计学意义(P<0.05,P<0.01),30例女性患者的AST、TBil、DBil、IBil、Glu、TC、TG、LDL-C、apo A-Ⅰ、non-HDL-C水平及apo B/apo A-Ⅰ、LDL-C/HDL-C、apo B/HDL-C、TC/HDL-C比值差异具有统计学意义(P<0.05,P<0.01)。non-HDL-C与TC、LDL-C、TG、HDL-C、apo A-Ⅰ、apo B、apo B/apo A-Ⅰ、TC/HDL均显著相关[相关系数(r)=0.4113～0.9893,P<0.01]。结论非酒精性脂肪肝普遍具有代谢异常和肝脏受损等特点,non-HDL-C的检测有助于全面了解非酒精性脂肪肝脂类代谢状况。更多还原

【Abstract】 Objective To study the clinical significance of serum non-high density lipoprotein cholesterol(non- HDL-C)level in patient with nonalcoholic fatty liver.Methods The levels of total protein(TP),albumin(Alb),glob- ulin(Glo),aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL),direct bilirubin (DBIL),immediate biliruhin(IBIL),glucose(Glu),total cholesterol(TC),triglycerides(TG),high density lipopro- tein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein A-Ⅰ(apoA-Ⅰ)and aimlipopro- tein B(apo B)were determined in 973 suhjects taken physical examination and the ratio of apo B/aim A-Ⅰ,LDL-C/ HDL-C,apo B/HDL-C and TC/HDL-C were calculated.These serum biochemical marks were analytically compared with those of 89 patients with nonalcoholic fatty liver and 202 healthy subjects.Results The detection rate of fatty liver was 9.15%.The rate of male patients(12.50%)was higher than that of female patients(5.99% ,P<0.05).There were significant differences between the levels of ALT,IBIL,TG,HDL-C,LDL-C,aim A-Ⅰ,non-HDL-C,aim B/apo A-Ⅰ,LDL-C/HDL-C,apo B/HDL-C and TC/HDL-C in 59 male patients and control group(P<0.05,P<0.01),also the levels of AST,TBIL,DBIL,IBIL,Gin,TC,TG,LDL-C,apo A-Ⅰ,non-HDL-C,apo B/apo A-Ⅰ,LDL-C/ HDL-C,apo B/HDL-C and TC/HDL-C in 30 female patients and control group(P<0.05,P<0.01).The non-HDL-C was obviously correlated with TC,LDL-C,TG,HDL-C,apo A-Ⅰ,apo B,apo B/apo A-Ⅰand TC/HDL-C(r= 0.4113～0.9893,P<0.01).Conclusions The metabolism disorders exist in patients with nonalcoholic fatty liver. Early determination of serum non-HDL-C level may be helpful to know the metabolism condition of plasma lipids.更多还原