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CTLA-4启动子区多态性与江南地区汉族人群SLE临床表型的相关性研究

Analysis of association of cytotoxic T lymphocyte-associated antigen-4 gene promoter polymorphisms with the clinical feathers of systemic lupus erythematosus in Han nationality population in South of the Changjiang River

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【作者】 齐媛媛杨晓惠孔令杰高淑娜江峰付朝伟王宝涛许爱娥孟炜

【Author】 QI Yuan-yuan1,YANG Xiao-hui2,KONG Ling-jie1,GAO Shu-na1,JIANG Feng1,FU Chao-wei1,WANG Bao-tao2,XU Ai-e3,MENG Wei1△(1Department of Epidemiology,School of Public Health,Fudan University,Shanghai 200032,China;2Department of Dermatology,The First Affiliated Hospital of Suzhou University,Suzhou 215006,Jiangsu Province,China;3Department of Dermatology,Third People’s Hospital of Hangzhou,Hangzhou 310009,Zhejiang Province,China)

【机构】 复旦大学公共卫生学院流行病学教研室苏州大学附属第一医院皮肤科杭州市第三人民医院皮肤科

【摘要】 目的探讨细胞毒性T淋巴细胞相关抗原-4(cytotoxic T lymphocyte-associated antigen 4,CTLA-4)基因启动子区多态性与系统性红斑狼疮(systemic lupus erythematosus,SLE)表型间的相关性。方法采用单纯病例研究,按临床表型和基因型、单倍型对120例女性SLE病人分组,分析基因与表型的相关性。结果-1722T>C位点-3、18C>T位点及单倍型与SLE各器官损害无关(P>0.05)。在抗SSA抗体阳性患者中,-1722T>C位点TT基因型的频率升高(P=0.020,OR=5.26,95%CI:1.30~21.32)。抗RNP抗体阳性患者中,-318C>T位点CT与TT合并基因型的频率降低(P=0.016,OR=0.16,95%CI:0.04~0.71)。两位点等位基因间存在连锁不平衡(P<0.05),且在抗SSA抗体阳性患者中,T-C单倍型频率升高(P=0.014,OR=1.90,95%CI:1.14~3.18),C-C单倍型频率降低(P=0.028,OR=0.55,95%CI:0.32~0.94);而在抗RNP抗体阳性患者中,T-T单倍型频率降低(P=0.029,OR=0.20,95%CI:0.05~0.85)。结论在江南地区汉族人群中,CTLA-4基因-1722T>C位点与抗SSA抗体的产生相关,-318C>T位点与抗RNP抗体的产生相关。

【Abstract】 Objective To explore the association between polymorphisms within cytotoxic T lymphocyte-associated antigen-4(CTLA-4) gene promoter and systemic lupus erythematosus(SLE) phenotypes in Han nationality population in South of the Changjiang River. Methods One hundred and twenty female cases were enrolled with the aim of case only design,and the genotype was determined by PCR-RFLP.Then,we calculated χ2 and ORs for related study. Results Analysis of association between the 2 SNPs and organ damage indicated no significant relationship(P>0.05).The-1722T/T genotype frequency in patients with positive anti-SSA was higher than that of patients with negative anti-SSA(P=0.020,OR=5.26,95%CI:1.30-21.32).The-318C/T and T/T combined group in patients with positive anti-RNP antibody had lower frequency than that of patients with negative anti-RNP antibody(P=0.016,OR=0.16,95%CI:0.04-0.71).Meanwhile,there was a linkage disequilibrium between the-1722T>C and-318C>T,so we analyzed the association between haplotypes and clinical feathers.In patients with positive anti-SSA,there was a relative high proportion in T-C haplotype(P=0.014,OR=1.90,95%CI:1.14-3.18),and a less one in C-C haplotype(P=0.028,OR=0.55,95%CI:0.32-0.94).Patients with positive anti-RNP antibody was found to have a lower frequency of T-T haplotype compared to patients with negative anti-RNP antibody(P=0.029,OR=0.20,95%CI:0.05-0.85). Conclusions In Han nationality population in South of the Changjiang River,-1722T>C allele may play an important role in the production of anti-SSA,and-318C>T allele may play an important role in the production of anti-RNP antibody.

【基金】 国家自然科学基金项目(30471485)
  • 【文献出处】 复旦学报(医学版) ,Fudan University Journal of Medical Sciences , 编辑部邮箱 ,2008年06期
  • 【分类号】R593.241
  • 【被引频次】3
  • 【下载频次】168
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