【摘要】 目的:探讨环氧化酶-2(COX-2)及碱性成纤维细胞生长因子(bFGF)在卵巢上皮性癌中的表达及意义。方法:采用免疫组化方法检测19例正常卵巢组织及50例卵巢上皮性癌中COX-2与bFGF的表达情况。结果:COX-2及bFGF在卵巢上皮性癌中的表达率分别为76%和78%,明显高于正常卵巢组织,两者在不同病理类型的卵巢上皮性癌中表达均无统计学差异,但在肿瘤的不同FIGO分期及分级中表达有统计学差异。COX-2与bFGF在卵巢上皮性癌中的表达有一致性。结论:COX-2及bFGF与卵巢上皮性癌的分化程度密切相关,检测COX-2及bFGF可作为判断卵巢上皮性癌恶性程度的生物学指标。更多还原

【Abstract】 Objective:To investigate the expression of cyclooxygenase 2(COX-2) and basic fibroblast growth factor (bFGF) in epithelial ovarian carcinoma tissues and its clinical significance.Methods:The immunohistochemical method was used to determine the expression of COX-2 and bFGF in 50 epithelia ovarian carcinomas and 19 normal ovarian tissues.Results:The positive rates of COX-2 and bFGF expression in ovarian carcinomas were 76% and 78% respectively,which were significantly higher than those in normal ovarian tissues. The expression rates were significantly different in different differentiation degree and FIGO grades,but not different between different histological types. There was a positive correlation between the expression of COX-2 and bFGF in ovarian carcinoma.Conclusions:Expression of COX-2 and bFGF is closely related to epithelial ovary carcinoma differentiation,and could be a helpful index of malignant degree.更多还原