【摘要】 目的探讨基质溶解素(MMP-7)及微血管密度(MVD)在肾癌肿瘤浸润转移中的作用。方法应用免疫组织化学SP法检测肾癌组织(163例)、正常肾组织(101例)中MMP-7表达和MVD,并分析其与肾癌临床病理参数的相关性。结果肾癌组织中MMP-7表达及MVD均显著高于正常肾组织(P<0.05),且两者呈显著正相关(r=0.341,P<0.01);MMP-7表达和MVD均与肾癌分期、肾包膜侵袭和淋巴结转移密切相关(P<0.05)。结论MMP-7、MVD与肾癌的浸润转移密切相关;降低MMP-7表达水平及抗肿瘤微血管形成是肾癌治疗的新目标。更多还原

【Abstract】 Objective To investigate the role and the significance of matrix metalloproteinase-7(MMP-7) on angiogenesis in renal cell carcinoma(RCC) through observing the relationship between the expression of MMP-7 and microvessel density(MVD) in RCC.Methods The expression of MMP-7 and CD34 in RCCs specimens were detected by immunohistochemistry(IHC) technique,and the clinical pathological parameters were analyzed on the same time.Results The positive rate of MMP-7 was 63.8% in RCC tissue.The expression of MMP-7 in RCC tissue,being significantly correlated with MVD in tumor(r=0.341,P<0.01),was remarkably higher than that in normal renal tissue(P<0.05).MMP-7 expression and MVD in tumor were closely related to clinical stage,renal fibromembrane invasion and lymph node metastasis(P<0.05).The higher the tumor stage,the higher the expression of MMP-7 and MVD.Conclusions The high expression of MMP-7 was significantly associated with MVD,biological behaviors of RCC,MMP-7 might be one of the important factors in the angiogenesis of RCC.更多还原