【摘要】 目的探讨游离与总量前列腺特异性抗原(PSA)比值(F-PSA/T-PSA)对T-PSA<4.0μg/L前列腺癌(PCa)早期诊断价值。方法采用电化学发光免疫分析技术检测136例正常健康男性(A组),87例T-PSA≥4.0μg/L PCa患者(B组)及12例T-PSA<4.0μg/L的PCa患者(C组)血清T-PSA和F-PSA,并计算F-PSA/T-PSA。结果A、B、C组T-PSA、F-PSA及F-PSA/T-PSA分别为(1.43±1.13)μg/L、(0.44±0.34)μg/L、0.36±0.15,(31.25±20.68)μg/L、(4.21±3.12)μg/L、0.17±0.08,(2.56±1.11)μg/L、(0.43±0.29)μg/L、0.18±0.09。A组T-PSA、F-PSA/T-PSA比较P均<0.01,B、C组的T-PSA、F-PSA相比P<均0.01,而F-PSA/T-PSA相比P>均0.05。将F-PSA/T-PSA分为<0.10、0.11~0.15、0.16~0.20、0.21~0.25、0.26~0.30以及>0.31 6个截点,在0.20截点以内C组患者占有率为75%,B组患者占有率为78%,两者0.20截点内占有率相比P>0.05。结论F-PSA/T-PSA对血清T-PSA≥4.0μg/L和<4μg/L的PCa患者均有良好的诊断价值更多还原

【Abstract】 Objective To evaluate the diagnosis value of F-PSA/T-PSA on early for prostate cancer(PCa) with prostate specific antigens(PSA) <4.0 μg/L.Methods The free and total PSA in 136 normal male volunteers(normal control),87 PCa patients with T-PSA≥4.0 μg/L and 12 patieats with T-PSA<4.0 μg/L were measured by electrochemiluminescence immunoassay.The ratios of F-PSA/T-PSA were therefore obtained.Results The T-PSA, F-PSA and F-PSA/T-PSA consisted of 1.43±1.13 μg/L,0.44±0.34 μg/L,0.36±0.15 in cases of normal control group;31.25±20.68 μg/L,4.21±3.12 μg/L,0.17±0.08 in 87 cases with T-PSA≥4.0 μg/L PCa cases;2.56±1.11 μg/L,0.43±0.29 μg/L,0.18±0.09 in 12cases with T-PSA<4.0 μg/L PCa cases.There is significant difference of T-PSA,F-PSA/T-PSA was observed between the normal control group and 12 PCa cases with <4.0 μg/L(P<0.01).Significant difference of T-PSA、 F-PSA and no difference of F-PSA/T-PSA between Pca with T-PSA≥4.0 μg/L and Pca with T-PSA <4.0 μg/L.The cut off of F-PSA/T-PSA were ranked as <0.10,0.11～0.15,0.16～0.20,0.21～0.25,0.26～0.30,>0.31.The 75% and 78.16% prevalence of PCa were observed in patients with T-PSA<4.0 μg/L PCa,T-PSA≥4.0 μg/L PCa respectively when F-PSA/T-PSA cutoff was less than 0.20(P>0.05).Conclusion The analysis of F-PSA/T-PSA is valuable for early diagnosis prostate cancer for patients with serum T-PSA≥4.0 μg/L and as low as <4.0 μg/L.更多还原