【摘要】 目的探讨β2肾上腺素受体(β2-AR)编码区16、27位点基因多态性与慢性阻塞性肺病(COPD)的关系。方法通过测序确定49例COPD患者(COPD组)和48例健康查体者(对照组)的基因突变类型,同时测定COPD组的第1秒用力呼气容积占预计值的百分比(FEV1%)。结果β2-AR编码区16、27位点基因频率和等位基因频率在COPD组与对照组间的分布无统计学差异(P>0.05);16位点基因多态性与FEV1%值显著相关(P<0.01),G ly/G ly与Arg/G ly基因型患者的FEV1%值低于Arg/Arg基因型患者。27位点基因多态性与FEV1%值显著相关(P<0.05),G ln/G ln与G ln/G lu基因型患者的FEV1%值低于G lu/G lu基因型患者。结论β2-AR16、27位点基因多态性可能不是COPD发病的基本原因,但其能够影响COPD患者的肺功能。更多还原

【Abstract】 Objective To investigate the relation between the polymorphisms of β2 adrenergic receptor(β2-AR) in 16,27 position and chronic obstructive pulmonary disease(COPD).Methods The genetic mutation types were determined by sequencing in 49 COPD patients(COPD group)and 48 healthy controls(control group),and FEV1% value in COPD group was detected.Results There was no difference in gene frequency and allele freauency of β2-AR coding region 16,27 site between COPD group and control group(P>0.05);β2-AR coding region 16 site polymorphism had significant relation with FEV1% value(P<0.01),FEV1% values of patients with Gly/Gly and Arg/Gly genotypes were lower than patients with Arg/Arg genotype. The polymorphism of β2-AR coding region 27 site had obvious relations with FEV1% value(P<0.05),FEV1% values of the patients with Gln/Gln and Gln/Glu genotype were lower than those of patients with Glu/Glu genotype.Conclusions Gene polymorphism of β2-AR coding region 16,27 site is not possible a primary cause of COPD,but it can influence pulmonary function of patients with COPD.更多还原