【摘要】 目的探讨血清鳞状细胞癌抗原(squamous cell carcinoma antigen,SCCAg)水平在鼻内翻性乳头状瘤(nasal inve-rted papilloma,NIP)手术前后的变化及其临床意义。方法采用微粒子酶免疫分析法(microparticle enzyme immunoassay,MEIA)检测34例NIP和12例(nasal squamous cell carcinoma,NSCC)患者手术前后血清SCCAg水平。结果34例NIP患者血清SCCAg阳性率为67.64%(23/34),12例NSCC患者血清SCCAg阳性率为75%(9/12),手术治疗前后患者血清鳞状细胞癌抗原水平变化差异有统计学意义(P<0.05)。复发患者SCCAg术后半年明显升高。结论治疗前后血清SCCAg值对估计NIP的生物学行为及评价治疗效果、预后有重要的参考价值。更多还原

【Abstract】 Objective To investigate the significance of the serum level of squamous cell carcinoma antigen(SCCAg) in nasal inverted papilloma(NIP).Methods The serum SCCAg levels were determined by micro-particle enzyme-immunoassay(MEIA) in 34 patients with NIP and 12 patients with nasal squamous cell carcinoma(NSCC) before and after the operations.Results The positive rate of squamous cell carcinoma antigen in 34 patients with NIP was 67.64%(23/34) and in 12 patients with NSCC it was 75%(9/12).The post-operative serum level of SCCAg had a statistical significance compared to that before the operations(P<0.05).The serum SCCAg levels in patients with recurrence significantly increased half a year later.Conclusion The SCCAg level plays an important role in evaluating the biological characteristics,therapeutic effects and prognosis in patients with NIP.更多还原