【摘要】 目的探讨氟西汀合并利培酮治疗难治性抑郁症的安全性和疗效。方法将92例难治性抑郁症患者随机分为两组,研究组采用氟西汀合并利培酮治疗,对照组采用氟西汀治疗,分别在治疗后第2、4、8、12周末,评定汉密顿抑郁量表(HAMD)和临床总体印象量表(CGI),同时采用Asberg抗抑郁剂副反应量表评定两组药物的副反应。结果根据HAMD评分,两组8周末减分率分别为(31.85±12.78)(、19.00±11.88),两组12周末减分率分别为(48.46±20.75)(、29.54±16.85),两组间差异均具有显著性意义(P<0.05)。根据CGI评分,两组8周末评分分别为(2.31±0.95)(、3.15±1.06),两组12周末评分分别为(2.00±1.00)、(2.92±1.19),两组间差异具有显著性意义(P<0.05)。药物副反应两组间无明显差异(P>0.05)。结论氟西汀联合利培酮治疗难治性抑郁症的疗效好,副反应无明显增加。更多还原

【Abstract】 Objective To study the efficacy and side effects of fluoxetine augmented with risperidone in the treatment of refractory depression.Methods A total of 92 patients with rifractory depression were randomly divided into study group(fluoxetine augmented with risperidone) and control group(fluoxetine) for treatment of 12 weeks.All subjects were assessed with Hamilton Rating Scale for Depression(HAMD),Clinical Global Impression(CGI),Asberg Rating Scale for Side Effects at the end of 2nd,4th,8th and 12th week.Results The rates of decreased scores of HAMD at the end of 8th week were(31.85±12.78)in study group and(19.00±11.88) in control group,at the end of 12th week were(48.46±20.75)and(29.54±16.85)respectively,there were significant differences between two groups(P<0.05).At the end of 8th week,the scores of CGI were(2.31±0.95)in study group,(3.15±1.06) in control group and at the end of 12th week were(2.00±1.00)and(2.92±1.19)respectively,there were significant differences between two groups(P<0.05).No significant difference in scores of Asberg Rating Scale for Side Effects were found between two groups(P>0.05).Conclusion Fluoxetine augmented with risperidone is effective in the treatment of refractory depression and doesn’ t increase side effects.更多还原